Search results for "CAMP response element binding"

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Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of…

2004

The expression level of neuronal nitric oxide synthase (nNOS) can vary depending on the (patho)physiological conditions. Here we document a marked induction of nNOS mRNA, protein, and total NO production in response to dibutyryl cyclic AMP (db-cAMP) in human A673 neuroepithelial cells. However, the upregulation of nNOS was associated with a decreased level of production of bioactive NO and by an increase in the level of generation of reactive oxygen species (ROS). ROS production could be prevented by the NOS inhibitor L-NAME, suggesting nNOS itself is involved in ROS generation. Sepiapterin supplementation of db-cAMP-treated A673 cells could restore full bioactive NO production, most likely…

CAMP-Responsive Element ModulatorNitric Oxide Synthase Type IBiologyCREBNitric OxideBiochemistryAdenylyl cyclaseCyclic AMP Response Element Modulatorchemistry.chemical_compoundMiceNeuroblastomaCoactivatorComplement C3b Inactivator ProteinsCyclic AMPAnimalsHumansNeuroectodermal Tumors Primitive PeripheralCREB-binding proteinEnzyme InhibitorsProtein kinase AeducationCyclic AMP Response Element-Binding ProteinGTP CyclohydrolaseCAMP response element bindingHomeodomain ProteinsNeuronseducation.field_of_studyForskolinPhosphoric Diester HydrolasesIntracellular Signaling Peptides and ProteinsBlood ProteinsLIM Domain ProteinsMolecular biologyCyclic AMP-Dependent Protein KinasesPterinsUp-RegulationDNA-Binding ProteinsRepressor ProteinsAntisense Elements (Genetics)NG-Nitroarginine Methyl EsterchemistryBucladesineGene Expression RegulationComplement Factor Hbiology.proteinNitric Oxide SynthaseReactive Oxygen SpeciesSignal TransductionBiochemistry
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Modulators of Endogenous Neuroprotection: Estrogen, Corticotropin-releasing Hormone and Endocannabinoids

2005

Age-associated neurodegenerative disorders are among the most challenging problems of our aging society. Alzheimer’s disease is affecting people with increasing frequency, since there is a clear relationship between the incidence of this detrimental disorder and age. Other neurodegenerative disorders, including Parkinson’s disease, stroke and amyotrophic lateral sclerosis, are also frequently observed in our aging society. For most of these diseases, no causal therapy has yet been identified. Many of the treatments given to patients that are affected by these disorders have different side effects, and therefore the search is on to identify novel molecular approaches that may lead to a more …

business.industrymedicine.drug_classCentral nervous systemEstrogen receptorDiseaseNeuroprotectionEndocannabinoid systemCorticotropin-releasing hormonemedicine.anatomical_structureEstrogenmedicinebusinessCAMP response element bindingNeuroscience
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